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Clinical Biology and Histopathology

The clinical and histopathology laboratories include sub-units dedicated to each specific activity. State-of-the art equipments include validated software (Pathdata, Bone, CITOX…) following GLP guidance in order to fulfil regulatory requirements.

Our team of certified and experienced pathologists (veterinarians and MD) and technical staff has a wealth of experience in evaluation of the safety of pharmaceutical, veterinary pharmaceutical, biotechnological, chemical, agrochemical and food and consumer products, in rodents and non-rodents.

Standard studies

Clinical pathology

Complete set of haematology, blood biochemistry and urinalysis parameters
Specific parameters: lipid profile, bone markers, hormones, cholinesterase
Coagulation parameters
Immunotoxicology: lymphocytes subset analysis, primary immune response to KLH

Sample analysis for multi-sites studies available

Necropsy

Tissue collection for frozen sections and imunohistochemistry
Bone collection for histomorphometry
Whole and upper body perfusion

Histology

Organ sampling and trimming according to RITA instructions for rodents
Paraffin and methacrylate embedding
Standardized and special staining procedures
Immunohistochemistry
Cryostat
Electron microscopy (blocks)

Histopathology

Evaluation of toxicological pathology, from acute to chronic toxicity and carcinogenicity studies, following the international recommendations for the terminology.
Historical control data for rodents (including different strains) and non-rodents routinely used at CIT.
Routine peer-review
Immunotoxicology
Histomorphometryr to quantify tissue changes
Complete pathology data entry and processing software from study set-up through necropsy and histopathology to the final pathology report (Pathdata software)
High resolution digital imaging, telepathology

Specific expertise

Tissue collection for RNA or DNA extraction

CIT provides a complete set of services in molecular pathology and genomics (transcriptomics).

Specifically trained team in order to:

- Collect the tissues in a very short time to avoid RNA degradation
- Trim the tissues to avoid contamination with adjacent tissues
- Follow specific procedures to avoid cross-contamination between tissues

Extensive list of tissues in rodent and non-rodent species.

Bone and joint research

CIT provides a complete set of services (in-vivo and ex-vivo) for the evaluation of the effects of products on the skeleton (pharmacological and toxicological effects).

Bone densitometry: standard radiology, DXA, pQCT, micro-CT
Histomorphometry: state-of-the-art facilities with validated software (BONE) for measurement of static and dynamic parameters
Complete set of blood and urine bone markers in rodent and non-rodent species

Histomorphometry

MORPHOEXPERT image analysis software allows quantification of user-defined changes for a wide range of parameters.

Molecular pathlogy

CIT offers molecular pathology services with real-time PCR (rt-PCR) and quantitative PCR (Q-PCR)

Subcontracting these activities to CIT is possible.

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