Request for LeadScreen proposal

Mini-Ames test * 2 strains : TA98, TA100  
3 strains : TA98, TA100 and TA102  
5 strains : TA98, TA100, TA102, TA1535 and TA1537  

Mini-Micronucleus test * Yes   No  

DevTOX and CardioTOX
In collaboration with Stemina
DevTOX  
CardioTOX  

Standard design with bioanalytical assays included * Bioanalytical assays included  
Bioanalytical assays included and option Bioanalysis method Set-up  

Early safety screening test by oral route (gavage) in Guinea Pigs *
3 animals, 5 successive sequences of 5 minutes infusion of escalating dose (1 vehicule 4 dose levels) followed by 10 minutes recovery. ECG parameters: heart rate, PQ, QRS, QT, QTb
Yes   No  

Exloratory toxicity study by oral route (gavage) in rats (1) *
Including BW, FC, Clinical Signs, Hemato-Biochemistry and Microcopic Examination
Yes   No  

(1) and option toxicokinetic * Yes   No  

(1) and option bioanalysis - Mehod set-up * Yes   No  

(1) and option Urine analysis *
Standard Urianalysis and Multiplex Biomarkers
Yes   No  

(1) and option Genomic *
RNA extraction, RNA microarray experiment, DrugMatrix analysis
Yes   No  

(1) and option micronucleus detection by flow cytometry * Yes   No