1. ICH S7A – Core Battery Studies (CNS)

Central Nervous system

• Irwin test and Functional Observation Battery (FOB) in rodents
• FOB in non-rodents

• Locomotor Activity (actimetry for rats or telemetry for all species)

• Motor coordination (rotarod test)

• Hexobarbital-induced sleeping time

 Cardiovascular system (CV) 

• Telemetry in non rodents (including primates, dogs and minipigs)

• Telemetry in rodents

• Orthostatic hypotension in dogs (tilt model)

• Anaesthetized preparations

Respiratory system

Whole body plethysmography in conscious rats and guinea-pigs

2. ICH S7A - Supplemental studies

Renal function

• Diuresis and ionic clearances

Gastro-intestinal system

• Charcoal transit time measurement

• Gastric emptying and secretion test

• Ulcer induction in rodents

Endocrine system

• Glucose tolerance test

• ACTH stimulation test

• Lipid Metabolism

• Uterotrophic assay

Coagulation

• Bleeding time

• Thrombosis models

3. ICH S7B - QT Prolongation and Arrhythmogenic Profile

In vivo

• Evaluation of QT prolongation by telemetry in conscious animals: (dogs, primates, minipigs and guinea-pig)
• Hypokalemic sensitised models (guinea pigs and dogs)
• Combined ECG and respiratory evaluations 

 In vitro

• Human Ether a go-go Related Gene (hERG) assay

• Purkinje fibres or papillary muscles action potential duration

Available under GLP conditions through partnerships

4. Safety pharmacology endpoints in toxicology

Central nervous system

• FOB in non-rodents

• Irwin test and FOB in rodents.

Cardiovascular system (CV)

• External Telemetry in non rodents (including primates, dogs and minipigs).
• Minimally invasive telemetry in non rodents.

Respiratory system

• Respiratory function in non rodents by external telemetry.
• Whole body plethysmography in conscious rats.

 Combining the evaluation of three functions in regulatory toxicology

 5. Early safety pharmacology screening battery for QT lengthening and Cardiovascular toxicity assessment

In vivo

• Anaesthetized model: guinea-pig
• Conscious model: guinea-pig with external telemetry device held in place by a jacket.

In vitro

• Human Ether a go-go Related Gene (hERG) assay.

6. Other pharmacological tests

General Pharmacology

• Ototoxicity evaluation by Auditory Brainstem Response (ABR),

• Sepsis model in mice (LPS) and primates (E. coli)

• Wound Healing

• Gastric emptying in NHPs

• Effect on triglyceride metabolism

• Other tests upon request

Disease models

• Hypo K+

• TdP models

• Cardiac hypertrophy

• Myocardial infarction,

• Hypertension

• Diabetes

• Hypercholesterolemia 

• Transgenic models

• Other diseases upon request.

Juvenile models