High quality animals from reliable breeders
- Cynomolgus monkeys from Maritius Island and Vietnam on site to start studies at your earlier convenience
- Cynomolgus monkeys from other origins (Fillipino, China) available upon request
- Rhesus monkeys from ChinaConfirmed mature monkeys available upon request
- Confirmed mature monkeys available upon request
A large portfolio of assays validated in many animal species
- KLH T-dependent antibody response (T-DAR) validated in rats, monkeys and dogs with reference immunosuppressive compounds:
- Quantitative assay in rats using Life Diagnostics kits for IgM and IgG
- Quantitative assay in monkeys using Life Diagnostics kits for IgM and IgG
- Quantitative assay in dogs using custom-purified anti-KLH IgM and IgG standards
- Lymphocyte subsets from circulating blood and lymphoid organs (i.e. lymph nodes, spleen, Peyer’s patches) of rats, dogs, monkeys (Cynomolgus):
- Rat : CD3, CD4, CD8, CD45R, CD20, CD16
- Monkey (cynomolgus) : CD3, CD4, CD8, CD20, CD16
- Dog : CD3, CD4, CD8, CD20
- Cytokine profiles in mice, and monkeys
- Fibrinogen and C-Reactive Protein (CRP) in rabbits for investigating vaccine reactogenicity
- Fibrinogen, CRP, Bb C3 and C3a complement factors and chimiokines (MIP1-a, MIP1-b and MCP1 in monkeys
- Cytokine profile in mice
Customized tests for the evaluation of pharmacological activities of biologics
- Special circulating sub-populations (i.e. NKT cells : NK11 (mouse), B-cell precursors : CD34 (cynomolgus)…) by flow cytometry
- Specific activated lymphocyte subset by flow cytometry (CD25 or iL2 receptor)
- Specific cell response to stimulation by ELISPOT (Th1, Th2)
- Antibody Dependent CytoToxicity (ADCC) assays (monitored by CD20)
- Lymphocyte proliferation assays (ConA, anti-CD3 stimulation…)
Immunogenicity testing of biologics
- Development or transfer and validation of dedicated assays (screening and confirmatory) by ELISA methods
- Transfer and validation of neutralization assays
Validated tests for contact allergy and photoallergy
- In vitro MUSST assay on dendritic-like U937 myeloid cell line
- Local lymph node assay (LLNA) in mice using the reference 3H-thymidine protocol
- Modified LLNA using –based vehicle for testing plant protection products
- Magnusson-Kliegman and Buehler tests in guinea pigs
- UV-LLNA test in mice for testing photo-toxic and photo-allergic potential of compounds by topical and oral administration
Immunohistochemistry and Tissue cross reactivity studies
- Optimization and validation of specific immunohistochemistry (IHC) staining on frozen or formalin-fixed tissues
- CD3, CD20, CD19
- CD11b (inflammatory cells), CD11c (dendritic cells), F4/80 (macrophages) for assessment of adjuvanticity in mice
- Tissue cross-reactivity studies (TCR) on panels of human and animal tissues
- Development or transfer and validation of assays, including relevant negative and positive controls
- Validated bank of tissues from healthy humans and animals including FDA and EMA recommended organs
- Special tissue banks (tumors, transgenic animals) prepared and validated upon request
Dedicated equipment
- 3-color Coulter and 10-color Navios (Beckman Coulter) flow cytometers
- Bioplex 200 (Biorad) Luminex equipment
- ELISA plate readers: Multiskan, Varioskan (Thermo Fischer)
- XT-Discovery (Ventana) for automatized IHC
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